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KMID : 0043320070300030381
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Archives of Pharmacal Research
2007 Volume.30 No. 3 p.381 ~ p.386
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A Novel Mucoadhesive Polymer Film Composed of Carbopol, Poloxamer and Hydroxypropylmethylcellulose
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Kim Tae-Hee
Ahn Jae-Soon
Choi Hu Kyun
Choi Yun-Jaie
Cho Chong-Su
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Abstract
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Using the casting method novel mucoadhesive polymer blend film consisting of Carbopol, poloxamer, and hydroxypropylmethylcellulose (HPMC) was prepared and characterized. Triamcinolone acetonide (TAA) was loaded into Carbopol/poloxamer/HPMC polymer blend film. Carbonyl band of Carbopol in Carbopol/poloxamer/HPMC shifted to longer wavenumber than that of Carbopol in Carbopol/poloxamer due to the hydrogen bonding among Carbopol, poloxamer, and HPMC. Tan δ peak assigned to glass transition temperature (Tg) of HPMC shifted to low temperature due to increased flexibility caused by increased poloxamer content in polymer blend films. Swelling ratio of Carbopol/poloxamer/HPMC films was lowest in Carbopol/ poloxamer/HPMC at mixing ratio of 35/30/35 (wt/wt/wt). Adhesive force of Carbopol/poloxamer/ HPMC films increased with increasing HPMC content in Carbopol/poloxamer/HPMC polymer blend film and increasing hydroxypropyl group content in HPMC due to hydrophobic property of HPMC although bioadhesive force was highest at mixing ratio of 35/30/35 (wt/wt/ wt). Release of TAA from TAA-loaded Carbopol/poloxamer/HPMC polymer blend film in vitro increased with increasing loading content of drug.
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KEYWORD
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Mucoadhesive, Polymer blend film, Carbopol, Poloxamer, Hydroxypropylmethyl cellulose, Transmucosal drug delivery
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